Design and methodology of the Aging Nephropathy Study (AGNES): a prospective cohort study of elderly patients with chronic kidney disease

Abstract Background Renal replacement therapy (RRT) is usually indicated for patients with chronic kidney disease (CKD) with glomerular filtration rate below 10 ml/ml/min/1.73m2.However, the need for RRT and timing of dialysis initiation are debatable for patients aged 70 years or older.We here describe the study design and methodology of the Aging

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HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure

Acute liver failure (ALF) is the culmination of severe liver cell injury from a variety of causes.ALF occurs when the extent of hepatocyte death exceeds the hepatic regenerative capacity.ALF has a high mortality that is merlin wizard costume associated with multiple organ failure (MOF) and sepsis; however, the underlying mechanisms are still not cl

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New Variant of SARS-CoV-2 Dynamics with Imperfect Vaccine

The occurrence of a new strain of SARS-CoV-2 cannot be ruled out.Therefore, this study seeks to investigate the possible effects of a hypothetical imperfect anti-COVID-19 vaccine on the control of not only the first simply southern cat shirt variant of SARS-CoV-2 but also the second (new) variant of SARS-CoV-2.We further examine the rates r and a,

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